Synaptic Plasticity, Metaplasticity and Depression
نویسندگان
چکیده
منابع مشابه
Synaptic Plasticity, Metaplasticity and Depression
The development of a persistent depressive affective state has for some time been thought to result from persistent alterations in neurotransmitter-mediated synaptic transmission. While the identity of those transmitters has changed over the years, the literature has lacked mechanistic connections between the neurophysiological mechanisms they regulate, and how these mechanisms alter neuronal f...
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In this paper, we review experimental evidence for a novel form of persistent synaptic plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it is not necessarily expressed as a change in the efficacy of normal synaptic transmission. Instead, it is manifest as a change in the ability to induce subsequent synaptic plasticity, such as long-term potenti...
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In many regions of the brain, the activity-dependent changes in synaptic strength depend on the frequency and timing of presynaptic stimulation and postsynaptic activity (synaptic plasticity), as well as the history of activity at those synapses (metaplasticity). The Bienenstock, Cooper and Munro (BCM) theory made several assumptions about how synapses modify and these have helped to guide vari...
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Addictive drugs such as cocaine induce synaptic plasticity in the ventral tegmental area and its projection areas, which may represent the cellular correlate of an addiction trace. Cocaine induces changes in excitatory transmission primarily in the VTA, which persists for days after a single exposure. These initial alterations in synaptic transmission represent a metaplasticity that is permissi...
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The results of expressing a constitutive form of a prominent synaptic kinase in transgenic mice suggest how there can be a sliding threshold for synapse modification, an important element in some learning theories. Experimental neuroscientists who work on synaptic plasticity usually spend their time down at the molecular level investigating basic mechanisms, whereas theoreti-cians who inhabit t...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2016
ISSN: 1570-159X
DOI: 10.2174/1570159x14666160202121111